Lye Brook Wilderness is a 17,841-acre (72 km2) wilderness area located northwest of Stratton, Vermont, within the Green Mountain National Forest. It is named after Lye Brook, which flows through the western half of the wilderness. Elevation within the wilderness ranges from 900 feet (274 m) to 2,900 feet (884 m) above sea level, though most lies on a high plateau above 2500 feet.
Approximately 80% of Lye Brook Wilderness is forested with northern hardwoods, such as birch, beech, and maple trees, though some thickets of small spruce dot the area as well. A variety of wildlife inhabit the area, including black bear, moose, deer, pine marten, bobcat, and various bird species.