The Clyde River is a main tributary which feeds the Seneca River in Seneca County, New York, United States. It begins at the hamlet of Lyons in nearby Wayne County and meanders for approximately 27 miles (43 kilometers) from west to east before emptying into the Seneca River in the town of Tyre at Montezuma National Wildlife Refuge. Much of the original river has been channeled through to form part of the Erie Canal. A number of tributaries feed the Clyde River along its route.
The Clyde River is part of the Seneca River watershed which feeds the Oswego River. From there, the Oswego River enters Lake Ontario. It is a primary spot for fishing, flatwater canoeing and kayaking.